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The Herpes simplex viruses are responsible for a broad-spectrum of diseases affecting all age groups across the developed and developing world. The viruses are members of the herpesvirus family, which also includes the human pathogens Varicella-Zoster virus, Epstein-Barr virus, Cytomegalovirus, Human herpes virus
commercial value of a HSV therapeutic vaccine across the major Western markets to 2035. 2016 WHO recommendations for the treatment of genital HSV HerpV (Agenus). COR-1 (Admedus). VCL-HB01/HM01 (Vical). HSV529 (Sanofi). HSV therapeutic vaccines: Commercial model assumptions. HSV target populations
3 Jun 2016 Both preventive and therapeutic vaccines for HSV-2 are being pursued and are in various stages of development. We will provide . HSV genital ulcer disease can be treated by the antiviral agent acyclovir, which is now included in WHO guidelines for syndromic management of GUD [21]. While episodic
Induction or expansion of CD4(+) and CD8(+) T cell responses are expected to be important for a successful therapeutic vaccine against HSV-2. A candidate vaccine consisting of 32 synthetic 35mer HSV-2 peptides non-covalently complexed with recombinant human Hsc70 protein (named HerpV, formerly AG-707) was
7 Nov 2013 Agenus Inc. (Nasdaq: AGEN), a developer of therapeutic vaccines for cancer and infectious diseases, today announced statistically significant top-line results from its Phase 2 randomized, double-blind, multi-center study for HerpV, a recombinant “off-the-shelf” therapeutic vaccine candidate for the treatment
30 Mar 2017 Your Dr. Halford can inject as many third world volunteers as he likes, but GEN003 will have FDA guidance through USA clinical trial based approval, . There are no existing therapeutic vaccines against any infectious diseases, so it is logical to assume that a vaccine maker would want its product to offer
21 Jul 2015 The global market value for genital herpes therapeutics will increase from approximately $490 million in 2013 to just under $668 million by 2023, largely driven by the introduction of therapeutic vaccines, HerpV and GEN-003, towards the end of the forecast period, says research and consulting firm
Separate PPCs for prophylactic and therapeutic vaccines. – Prophylactic ideal for LMICs but therapeutic available first Clinical Trials. Vaccine. Company. Candidate. Adjuvant. Current Phase. Results. Synthetic peptide complex with. HHSP 70. Agenus. HerpV. 32 peptides. QS-21. II, therapeutic. 17% reduction in shedding.
31 May 2017 Infection with herpes simplex virus type 2 (HSV-2) can be transmitted via asymptomatic viral shedding and produce recurrent genital lesions. Current.
Keywords: animal models, genital herpes, herpes simplex virus, immune response, prophylactic vaccine, therapeutic vaccine. Go to: .. Koelle et al. tested a vaccine (HerpV) consisting of recombinant heat shock protein (rhHsc70), an array of HSV-2 peptides (32 synthetic 35 mers predicted to contain HSV-2-specific T-cell
     

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